USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P61086 USC-OGP 2-DE database:  P61086 P61086 General information about the entry View entry in simple text format Entry name UBE2K_HUMAN Primary accession number P61086 Secondary accession number(s) P27924 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Ubiquitin-conjugating enzyme E2 K; EC=2.3.2.23 {ECO:0000269|PubMed:20061386}; AltName: Full=E2 ubiquitin-conjugating enzyme K; AltName: Full=Huntingtin-interacting protein 2; Short=HIP-2; AltName: Full=Ubiquitin carrier protein; AltName: Full=Ubiquitin-conjugating enzyme E2-25 kDa; Short=Ubiquitin-conjugating enzyme E2(25K); Short=Ubiquitin-conjugating enzyme E2-25K; AltName: Full=Ubiquitin-protein ligase;. Gene name Name=UBE2K Synonyms=HIP2, LIG Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0211: pI=4.88; Mw=22897 PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0542: pI=5.14; Mw=23700 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0821: pI=5.15; Mw=23512 Cross-references UniProtKB/Swiss-Prot P61086; UBE2K_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name UBE2K_HUMAN Primary accession number P61086 Secondary accession number(s) A6NJC1 A8K5Y9 B2RDF8 C9JGP1 O54806 P27924 Q16721 Q9CVV9 Q9Y2D3 Sequence was last modified on  January 23, 2007 (version 3) Annotations were last modified on  March 15, 2017 (version 149) Name and origin of the protein Description RecName: Full=Ubiquitin-conjugating enzyme E2 K; EC=2.3.2.23 {ECO:0000269|PubMed:20061386}; AltName: Full=E2 ubiquitin-conjugating enzyme K; AltName: Full=Huntingtin-interacting protein 2; Short=HIP-2; AltName: Full=Ubiquitin carrier protein; AltName: Full=Ubiquitin-conjugating enzyme E2-25 kDa; Short=Ubiquitin-conjugating enzyme E2(25K); Short=Ubiquitin-conjugating enzyme E2-25K; AltName: Full=Ubiquitin-protein ligase; Gene name Name=UBE2K Synonyms=HIP2, LIG Encoded on Name=UBE2K; Synonyms=HIP2, LIG Keywords 3D-structure; Acetylation; Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Isopeptide bond; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Ubl conjugation; Ubl conjugation pathway. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U58522; AAC50633.1; -; mRNA EMBL AB022435; BAA78555.1; -; mRNA EMBL AB022436; BAA78556.1; -; mRNA EMBL BX339118; -; NOT_ANNOTATED_CDS; mRNA EMBL AK291454; BAF84143.1; -; mRNA EMBL AK315524; BAG37905.1; -; mRNA EMBL AC105287; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC108471; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471069; EAW92948.1; -; Genomic_DNA EMBL BC022804; AAH22804.1; -; mRNA EMBL BC050600; AAH50600.1; -; mRNA CCDS CCDS33976.1; -. [P61086-1]; . CCDS CCDS47043.1; -. [P61086-3]; . CCDS CCDS47044.1; -. [P61086-2]; . RefSeq NP_001104582.1; NM_001111112.1. [P61086-3]; . RefSeq NP_001104583.1; NM_001111113.1. [P61086-2]; . RefSeq NP_005330.1; NM_005339.4. [P61086-1]; . UniGene Hs.50308; -; . PDB 1YLA; X-ray; 2.40 A; A/B=1-200 PDB 2O25; X-ray; 2.60 A; A/B=1-200 PDB 3E46; X-ray; 1.86 A; A=1-200 PDB 3F92; X-ray; 2.23 A; A=13-200 PDB 3K9O; X-ray; 1.80 A; A=1-200 PDB 3K9P; X-ray; 2.80 A; A=1-200 PDB 5DFL; X-ray; 2.10 A; A=1-200 PDBsum 1YLA; -; . PDBsum 2O25; -; . PDBsum 3E46; -; . PDBsum 3F92; -; . PDBsum 3K9O; -; . PDBsum 3K9P; -; . PDBsum 5DFL; -; . ProteinModelPortal P61086; -; . SMR P61086; -; . BioGrid 109340; 92; . DIP DIP-32524N; -; . IntAct P61086; 40; . MINT MINT-5000019; -; . STRING 9606.ENSP00000261427; -; . iPTMnet P61086; -; . PhosphoSitePlus P61086; -; . SwissPalm P61086; -; . BioMuta UBE2K; -; . DMDM 46577658; -; . OGP P27924; -; . EPD P61086; -; . MaxQB P61086; -; . PaxDb P61086; -; . PeptideAtlas P61086; -; . PRIDE P61086; -; . TopDownProteomics P61086-1; -. [P61086-1]; . DNASU 3093; -; . Ensembl ENST00000261427; ENSP00000261427; ENSG00000078140. [P61086-1]; . Ensembl ENST00000445950; ENSP00000390483; ENSG00000078140. [P61086-3]; . Ensembl ENST00000503368; ENSP00000421203; ENSG00000078140. [P61086-2]; . GeneID 3093; -; . KEGG hsa:3093; -; . UCSC uc003gus.5; human. [P61086-1]; . CTD 3093; -; . DisGeNET 3093; -; . GeneCards UBE2K; -; . HGNC HGNC:4914; UBE2K; . HPA CAB033212; -; . HPA CAB033515; -; . HPA HPA028869; -; . MIM 602846; gene; . neXtProt NX_P61086; -; . OpenTargets ENSG00000078140; -; . PharmGKB PA162407874; -; . eggNOG KOG0418; Eukaryota; . eggNOG COG5078; LUCA; . GeneTree ENSGT00670000098059; -; . HOGENOM HOG000233455; -; . HOVERGEN HBG063308; -; . InParanoid P61086; -; . KO K04649; -; . OMA HEMFILT; -; . OrthoDB EOG091G0KVW; -; . PhylomeDB P61086; -; . TreeFam TF101127; -; . BRENDA 2.3.2.B6; 2681; . Reactome R-HSA-8866652; Synthesis of active ubiquitin: roles of E1 and E2 enzymes; . Reactome R-HSA-936440; Negative regulators of RIG-I/MDA5 signaling; . Reactome R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation; . SignaLink P61086; -; . UniPathway UPA00143; -; . ChiTaRS UBE2K; human; . EvolutionaryTrace P61086; -; . GeneWiki HIP2; -; . GenomeRNAi 3093; -; . PRO PR:P61086; -; . Proteomes UP000005640; Chromosome 4; . Bgee ENSG00000078140; -; . CleanEx HS_UBE2K; -; . ExpressionAtlas P61086; baseline and differential; . Genevisible P61086; HS; . GO GO:0005737; C:cytoplasm; IBA:GO_Central; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0032433; C:filopodium tip; IEA:Ensembl; . GO GO:0005634; C:nucleus; IBA:GO_Central; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB; . GO GO:0004842; F:ubiquitin-protein transferase activity; IDA:UniProtKB; . GO GO:0034450; F:ubiquitin-ubiquitin ligase activity; IDA:UniProtKB; . GO GO:0035458; P:cellular response to interferon-beta; IMP:UniProtKB; . GO GO:0010994; P:free ubiquitin chain polymerization; IDA:UniProtKB; . GO GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl; . GO GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IDA:UniProtKB; . GO GO:0060340; P:positive regulation of type I interferon-mediated signaling pathway; IMP:UniProtKB; . GO GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central; . GO GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB; . GO GO:0016567; P:protein ubiquitination; TAS:Reactome; . GO GO:0032434; P:regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl; . GO GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:ProtInc; . Gene3D 3.10.110.10; -; 1; . InterPro IPR015940; UBA; . InterPro IPR009060; UBA-like; . InterPro IPR000608; UBQ-conjugat_E2; . InterPro IPR023313; UBQ-conjugating_AS; . InterPro IPR016135; UBQ-conjugating_enzyme/RWD; . Pfam PF00627; UBA; 1; . Pfam PF00179; UQ_con; 1; . SMART SM00165; UBA; 1; . SUPFAM SSF46934; SSF46934; 1; . SUPFAM SSF54495; SSF54495; 1; . PROSITE PS50030; UBA; 1; . PROSITE PS00183; UBIQUITIN_CONJUGAT_1; 1; . PROSITE PS50127; UBIQUITIN_CONJUGAT_2; 1; .

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